My 92 year old mother was prescribed Lodine for arthritis pain, after trying a myriad of other drugs. The doctors were concerned about stomach irritation and other side-effects, though they said this was a mild anti-arthritic. Although it helped some, her knees are so bad that nothing really works to give her pain relief. Recently my mother's blood work indicated that her kidney function test was out of range, so the doctor pulled her off the Lodine. She is now just taking Tylenol 3, which has not done much to help the pain and has increased her constipation. We need to see if her kidneys bounce back, otherwise we'll have to see a kidney specialist. So just a warning about extended use of Lodine.